Perfusion MRI
 
PersonnelM.J.P. van Osch
 J. Hendrikse
 J. van der Grond
 E.P.A. Vonken
 C.J.G. Bakker
CollaborationPhilips Medical Systems
Begin01-09-1997
Purpose and ScopeThe quantitative measurement of cerebral perfusion by bolus-tracking MRI or non-invasive MRI techniques.
Results Obtained
  • The development of a dual echo bolus-tracking MRI sequence to prevent T1-influence on the contrast agent concentration measurement.
  • PublicationsPapers in international journals
     [1] M.J.P. van Osch, E.J. Vonken, M.A. Viergever, J. van der Grond, C.J.G. Bakker, "Measuring the arterial input function with gradient echo sequences", Magnetic Resonance in Medicine, 2003, vol. 49, pp. 1067-1076.
     [2] D.R. Rutgers, M.J.P. van Osch, L.J. Kapelle, W.P.Th.M. Mali, J. van der Grond, "Cerebral hemodynamics and metabolism in patients with a symptomatic occlusion of the internal carotid artery", Stroke, 2003, vol. 34, pp. 648-652.
     [3] J. Schepers, M.J.P. van Osch, K. Nicolay, "Effect of vascular crushing on FAIR perfusion kinetics,using a BIR-4 pulse in a magnetization prepared FLASH sequence", Magnetic Resonance in Medicine, 2003, vol. 50, pp. 608-613.
     [4] M.J.P. van Osch, E.P.A. Vonken, O. Wu, M.A. Viergever, J. van der Grond, C.J.G. Bakker, "Model of the human vasculature for studying the influence of contrast injection speed on cerebral perfusion MRI", Magnetic Resonance in Medicine, 2003, vol. 50, pp. 614-622.
     [5] M.J.P. van Osch, D.R. Rutgers, E.J. Vonken, A.C. van Huffelen, C.J.M. Klijn, C.J.G. Bakker, J. van der Grond, "Quantitative cerebral perfusion MRI and CO2 reactivity measurements in patients with symptomatic internal carotid artery occlusion", NeuroImage, 2002, vol. 17, pp. 469-478.
     [6] M.J.P. van Osch, E.P.A. Vonken, C.J.G. Bakker, M.A. Viergever, "Correcting partial volume artifacts of the arterial input function in quantitative cerebral perfusion MRI", Magnetic Resonance in Medicine, 2001, vol. 45, pp. 477-485.
     [7] E.P.A. Vonken, M.J.P. van Osch, C.J.G. Bakker, M.A. Viergever, "Simultaneous quantitative cerebral perfusion and Gd-DTPA extravasation measurement with dual-echo dynamic susceptibility contrast MRI", Magnetic Resonance in Medicine, 2000, vol. 43, pp. 820-827.
     [8] E.P.A. Vonken, M.J.P. van Osch, P.W.A. Willems, A. van der Zwan, C.J.G. Bakker, M.A. Viergever, W.P.T.M. Mali, "Repeated quantitative perfusion and contrast permeability measurement in the MRI examination of a CNS tumor", European Radiology, 2000, vol. 10, pp. 1447-1451.
     Abstracts
     [9] M.J.P. van Osch, J. van der Grond, M.A. Viergever, C.J.G. Bakker, "A model of the human vasculature for studying the influence of the contrast injection speed on cerebral perfusion MRI", International Society Magnetic Resonance in Medicine, 2003, p. 2187.
     [10] J. Schepers, M.J.P. van Osch, L.W. Bartels, S.N. Heukels, K. Nicolay, "Quantification of perfusion by pulsed arterial spin labeling (PASL) techniques like FAIR can be affected by inflow of unlabeled blood. In this study", International Society Magnetic Resonance in Medicine, 2003.
     [11] M.J.P. van Osch, E.J. Vonken, C.J.G. Bakker, M.A. Viergever, "Measurement of a calibration curve of Gd-DTPA in flowing human blood for arterial input function measurements", International Society Magnetic Resonance in Medicine, 2002.
     [12] M.J.P. van Osch, P.A.F. Jansen, R.W. Vingerhoets, J. van der Grond, "Quantitative perfusion and spectroscopic imaging of geriatric patients with orthostatic hypotension", International Society Magnetic Resonance in Medicine, 2002.
     [13] M.J.P. van Osch, C.J.G. Bakker, M.A. Viergever, "Arterial input function measurements with gradient echo sequences", International Society Magnetic Resonance in Medicine, 2001.
     [14] M.J.P. van Osch, E.J. Vonken, J. van der Grond, C.J.G. Bakker, M.A. Viergever, "Quantitative assessment of perfusion and blood-brain-barrier permeability in brain tumors by MRI", European Congres of Radiology, 2000.
     [15] M.J.P. van Osch, E.J. Vonken, C.J.G. Bakker, J. van der Grond, M.A. Viergever, "Quantitative perfusion imaging: methods and results", International Society Magnetic Resonance in Medicine, 2000.
     [16] M.J.P. van Osch, C.J.G. Bakker, M.A. Viergever, "In vitro determination of MR-properties of gadolinium in flowing blood for arterial input function measurements", International Society Magnetic Resonance in Medicine, 2000.
     [17] M.J.P. van Osch, E.J. Vonken, C.J.G. Bakker, M.A. Viergever, "Determination of the arterial input function in 3D quantitative perfusion imaging by means of a test bolus", International Society Magnetic Resonance in Medicine, 1999.
     [18] M.J.P. van Osch, E.J. Vonken, K.L. Vincken, C.J.G. Bakker, M.A. Viergever, "Complex analysis of the arterial input function", International Society Magnetic Resonance in Medicine, 1999.