publication

Neural correlates of intolerance of uncertainty in clinical disorders

Wever, Mirjam, Smeets, Paul, Sternheim, Lot

DOI: https://doi.org/10.1176/appi.neuropsych.14120387

Journal of Neuropsychiatry and Clinical Neuroscience 27 (4), p. 345-353

Abstract

Intolerance of uncertainty is a key contributor to anxiety-related disorders. Recent studies highlight its importance in other clinical disorders. The link between its clinical presentation and the underlying neural correlates remains unclear. This review summarizes the emerging literature on the neural correlates of intolerance of uncertainty. In conclusion, studies focusing on the neural correlates of this construct are sparse, and findings are inconsistent across disorders. Future research should identify neural correlates of intolerance of uncertainty in more detail. This may unravel the neurobiology of a wide variety of clinical disorders and pave the way for novel therapeutic targets.