publication

First clinical experience with a dedicated MRI-guided high-intensity focused ultrasound system for breast cancer ablation

Merckel, LG, Knuttel, Floor M, Deckers, Roel, van Dalen, Thijs, Schubert, Gerald, Peters, Nicky H G M, Weits, Teun, van Diest, Paul J, Mali, Willem P Th M, Vaessen, Paul H H B, van Gorp, Joost M H H, Moonen, Chrit T W, Bartels, Lambertus W, van den Bosch, Maurice A A J

DOI: https://doi.org/10.1007/s00330-016-4222-9

European Radiology 26 (11), p. 4037-4046

Abstract

OBJECTIVES: To assess the safety and feasibility of MRI-guided high-intensity focused ultrasound (MR-HIFU) ablation in breast cancer patients using a dedicated breast platform.

METHODS: Patients with early-stage invasive breast cancer underwent partial tumour ablation prior to surgical resection. MR-HIFU ablation was performed using proton resonance frequency shift MR thermometry and an MR-HIFU system specifically designed for breast tumour ablation. The presence and extent of tumour necrosis was assessed by histopathological analysis of the surgical specimen. Pearson correlation coefficients were calculated to assess the relationship between sonication parameters, temperature increase and size of tumour necrosis at histopathology.

RESULTS: Ten female patients underwent MR-HIFU treatment. No skin redness or burns were observed in any of the patients. No correlation was found between the applied energy and the temperature increase. In six patients, tumour necrosis was observed with a maximum diameter of 3-11 mm. In these patients, the number of targeted locations was equal to the number of areas with tumour necrosis. A good correlation was found between the applied energy and the size of tumour necrosis at histopathology (Pearson = 0.76, p = 0.002).

CONCLUSIONS: Our results show that MR-HIFU ablation with the dedicated breast system is safe and results in histopathologically proven tumour necrosis.

KEY POINTS: • MR-HIFU ablation with the dedicated breast system is safe and feasible • In none of the patients was skin redness or burns observed • No correlation was found between the applied energy and the temperature increase • The correlation between applied energy and size of tumour necrosis was good.