publication

Visuospatial Functioning in Cerebral Amyloid Angiopathy: A Pilot Study

Valenti, Raffaella, Charidimou, Andreas, Xiong, Li, Boulouis, Gregoire, Fotiadis, Panagiotis, Ayres, Alison, Riley, Grace, Kuijf, Hugo J., Reijmer, Yael D., Pantoni, Leonardo, Gurol, M. Edip, Davidsdottir, Sigurros, Greenberg, Steven M., Viswanathan, Anand

DOI: https://doi.org/10.3233/JAD-160927

Journal of Alzheimer's Disease 56 (4), p. 1223-1227

Abstract

Cerebral amyloid angiopathy (CAA) is a contributor to cognitive impairment in the elderly. We hypothesized that the posterior cortical predilection of CAA would cause visual-processing impairment. We systematically evaluated visuospatial abilities in 22 non-demented CAA patients. Neurocognitive evaluation demonstrated visuoperceptual impairment (23 on Benton Facial Recognition Test [BFRT] and 13.6 on Benton Judgment of Line Orientation Test [BJLO]). BFRT was inversely correlated with white matter hyperintensities volume and BJLO with parietal cerebral microbleeds. This pilot study highlights the presence of visual-processing deficits in CAA. The impairment could be related to global disease severity in addition to local brain injury.