Marijn van Stralen

From the start of my PhD I have been investigating non-invasive imaging technologies for diagnosis, monitoring and treatment guidance. My PhD, at LUMC and ErasmusMC, focused on automated analysis of 3D echocardiography, aiming at positioning 3D ultrasound as a non-invasive modality for 3D assessment of left ventricular function. During my postdocs at UMCU, I broadened my research interests and skills into US & MR brain image analysis (brainshift registration & segmentation, for intraoperative guidance), abdominal MR (DCE-MRI & ASL-MRI), CT spine (scoliosis analysis). The abdominal MR work has led to the development of Drag and drop ASL, offering perfusion imaging in the abdomen without the need for intravenous contrast injection.
The past years, together with Peter Seevinck, I have been developing BoneMRI, software-enabled visualization of bone using MRI, within a close collaboration between UMCU and newly founded company MRIguidance. This has developed into a research line aiming at 1. further improving the image quality for investigating the diagnostic use of synthetic CTs, obviating the need for an additional CT and reducing dose, and 2. developing synthetic CT for monitoring and treatment guidance, obviating the need for the often dedicated, additional CT.

Publications

• Deep learning-based MR-to-CT synthesis: The influence of varying gradient echo-based MR images as input channels
  Florkow, Mateusz C, Zijlstra, Frank, Willemsen, Koen, Maspero, Matteo, van den Berg, Cornelis A T, Kerkmeijer, Linda G W, Castelein, René M, Weinans, Harrie, Viergever, Max A, van Stralen, Marijn, Seevinck, Peter R Apr 2020 in Magnetic Resonance in Medicine 83 (4), p. 1429-1441
• Comparison of multi-delay FAIR and pCASL labeling approaches for renal perfusion quantification at 3T MRI
  Harteveld, Anita A, de Boer, Anneloes, Franklin, Suzanne Lisa, Leiner, Tim, van Stralen, Marijn, Bos, Clemens Feb 2020 in Magma - Magnetic Resonance Materials In Physics Biology And Medicine 33 (1), p. 81-94
• Dosimetric evaluation of synthetic CT for head and neck radiotherapy generated by a patch-based three-dimensional convolutional neural network
  Dinkla, Anna M, Florkow, Mateusz C, Maspero, Matteo, Savenije, Mark H F, Zijlstra, Frank, Doornaert, Patricia A H, van Stralen, Marijn, Philippens, Marielle E P, van den Berg, Cornelis A T, Seevinck, Peter R Sep 2019 in Medical Physics 46 (9), p. 4095-4104
• Deep learning enables automatic quantitative assessment of puborectalis muscle and urogenital hiatus in plane of minimal hiatal dimensions
  van den Noort, F, van der Vaart, C H, Grob, A T M, van de Waarsenburg, M K, Slump, C H, van Stralen, M Aug 2019 in Ultrasound in Obstetrics and Gynecology 54 (2), p. 270-275
• Enabling free-breathing background suppressed renal pCASL using fat imaging and retrospective motion correction
  Bones, Isabell K, Harteveld, Anita A, Franklin, Suzanne L, van Osch, Matthias J P, Hendrikse, Jeroen, Moonen, Chrit T W, Bos, Clemens, van Stralen, Marijn Jul 2019 in Magnetic Resonance in Medicine 82 (1), p. 276-288
• Surgical Outcomes of Anterior Versus Posterior Fusion in Lenke Type 1 Adolescent Idiopathic Scoliosis
  Vavruch, Ludvig, Brink, Rob C., Malmqvist, Marcus, Schlösser, Tom P.C., van Stralen, Marijn, Abul-Kasim, Kasim, Ohlin, Acke, Castelein, René M., Tropp, Hans Jul 2019 in Spine 44 (14), p. E823-E832
• The changing position of the center of mass of the thorax during growth in relation to pre-existent vertebral rotation
  De Reuver, Steven, Brink, Rob C., Homans, Jelle F., Kruyt, Moyo C., Van Stralen, Marijn, Schlösser, Tom P.C., Castelein, René M. May 2019 in Spine 44 (10), p. 679-684
• Synthetic CT generation for Head and Neck radiotherapy by a 3D convolutional neural network
  Dinkla, A., Florkow, M., Maspero, M., Savenije, M., Zijlstra, F., Doornaert, P., Van Stralen, M., Philippens, M., Seevinck, P., Van den Berg, N. Apr 2019 in Radiotherapy & Oncology 133 p. S268-S269
• CT-based study of vertebral and intravertebral rotation in right thoracic adolescent idiopathic scoliosis
  Brink, Rob C., Homans, Jelle F., Schlösser, Tom P.C., van Stralen, Marijn, Vincken, Koen L., Shi, Lin, Chu, Winnie C.W., Viergever, Max A., Castelein, René M., Cheng, Jack C.Y. Dec 2019 in European Spine Journal 28 (12), p. 3044-3052
• The impact of MRI-CT registration errors on deep learning-based synthetic CT generation
  Florkow, Mateusz C., Zijlstra, Frank, Kerkmeijer, Linda G.W., Maspero, Matteo, Van Den Berg, Cornelis A.T., Van Stralen, Marijn, Seevinck, Peter R. jan 2019 in The impact of MRI-CT registration errors on deep learning-based synthetic CT generation: Medical Imaging 2019 p. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10949)
• CT synthesis from MR images for orthopedic applications in the lower arm using a conditional generative adversarial network
  Zijlstra, F., Willemsen, K., Florkow, M. C., Sakkers, R. J.B., Weinans, H. H., Van Der Wal, B. C.H., Van Stralen, M., Seevinck, P. R. jan 2019 in CT synthesis from MR images for orthopedic applications in the lower arm using a conditional generative adversarial network: Medical Imaging 2019 p. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10949)
• The anterior longitudinal ligament in diffuse idiopathic skeletal hyperostosis: ossified or displaced?
  Kuperus, Jonneke S., Smit, Esther J. M., Pouran, Behdad, van Hamersvelt, Robbert W., van Stralen, Marijn, Seevinck, Peter R., Buckens, Constantinus F., Bleys, Ronald L. A. W., Weinans, Harrie H., Oner, F. Cumhur, de Jong, Pim A., Verlaan, Jorrit-Jan Sep 2018 in Journal of Orthopaedic Research 36 (9), p. 2491-2496
• Selection Strategies for Atlas-Based Mosaicing of Left Atrial 3-D Transesophageal Echocardiography Data
  Mulder, Harriët W., van Stralen, Marijn, Ren, Ben, Haak, Alexander, van Burken, Gerard, Viergever, Max A., Bosch, Johan G., Pluim, Josien P.W. Jul 2018 in Ultrasound in Medicine and Biology 44 (7), p. 1533-1543
• Automatic segmentation of puborectalis muscle on three-dimensional transperineal ultrasound
  van den Noort, F., Grob, A. T.M., Slump, C. H., van der Vaart, C. H., van Stralen, M. Jul 2018 in Ultrasound in Obstetrics and Gynecology 52 (1), p. 97-102
• Fluid filling of the digestive tract for improved proton resonance frequency shift-based MR thermometry in the pancreas
  Ferrer, Cyril J, Bartels, Lambertus W, van Stralen, Marijn, Denis de Senneville, Baudouin, Moonen, Chrit T W, Bos, Clemens Mar 2018 in Journal of Magnetic Resonance Imaging 47 (3), p. 692-701
• Contextual loss functions for optimization of convolutional neural networks generating pseudo CTs from MRI
  Van Stralen, M., Zhou, Y., Wozny, P. J., Seevinck, P. R., Loog, M. mar 2018 in Contextual loss functions for optimization of convolutional neural networks generating pseudo CTs from MRI: Medical Imaging 2018 p. (SPIE Proceedings; vol. 10574)
• Anterior-posterior length discrepancy of the spinal column in adolescent idiopathic scoliosis—a 3D CT study
  Brink, Rob C., Schlösser, Tom P.C., van Stralen, Marijn, Vincken, Koen L., Kruyt, Moyo C., Hui, Steve C.N., Viergever, Max A., Chu, Winnie C.W., Cheng, Jack C.Y., Castelein, René M. Dec 2018 in The Spine Journal 18 (12), p. 2259-2265
• Benchmarking Distance Control and Virtual Drilling for Lateral Skull Base Surgery
  Voormolen, Eduard H.J., Diederen, Sander, van Stralen, Marijn, Woerdeman, Peter A., Noordmans, Herke Jan, Viergever, Max A., Regli, Luca, Robe, Pierre A., Berkelbach vd Sprenkel, JW Jan 2018 in World Neurosurgery 109 p. e217-e228
• What is the Actual 3D Representation of the Rib Vertebra Angle Difference (Mehta Angle)?
  Brink, Rob C, Schlösser, Tom P C, van Stralen, Marijn, Vincken, Koen L, Kruyt, Moyo C, Chu, Winnie C W, Cheng, Jack C Y, Castelein, RM 2018 in Spine 43 (2), p. E92-E97
• Predicting clinical benefit from everolimus in patients with advanced solid tumors, the CPCT-03 study
  Weeber, Fleur, Cirkel, Geert A., Hoogstraat, Marlous, Bins, Sander, Gadellaa-van Hooijdonk, Christa G.M., Ooft, Salo, van Werkhoven, Erik, Willems, Stefan M., van Stralen, Marijn, Veldhuis, Wouter B., Besselink, Nicolle J M, Horlings, Hugo M, Steeghs, Neeltje, de Jonge, Maja J., Langenberg, Marlies H.G., Wessels, Lodewyk F A, Cuppen, Edwin P.J.G., Schellens, J.H., Sleijfer, Stefan, Lolkema, Martijn P., Voest, Emile E. Aug 2017 in Oncotarget 8 (33), p. 55582-55592
• Anterior Spinal Overgrowth is the Result of the Scoliotic Mechanism and is Located in the Disc
  Brink, Rob C, Schlösser, Tom P C, Colo, Dino, Vavruch, Ludvig, van Stralen, Marijn , Vincken, Koen L , Malmqvist, Marcus, Kruyt, Moyo C, Tropp, Hans, Castelein, RM Jun 2017 in Spine 42 (11), p. 818-822
• Atlas-Based Mosaicing of Left Atrial 3-D Transesophageal Echocardiography Images
  Mulder, Harriët W., van Stralen, Marijn, Ren, Ben, Haak, Alexander, Viergever, Max A., Bosch, Johan G., Pluim, JPW Apr 2017 in Ultrasound in Medicine and Biology 3 (4), p. 765-774
• The Height-Width-Depth Ratios of the Intervertebral Discs and Vertebral Bodies in Adolescent Idiopathic Scoliosis vs Controls in a Chinese Population
  Chen, Hao, Schlösser, Tom P.C., Brink, Rob C., Colo, DIno, Van Stralen, Marijn, Shi, Lin, Chu, Winnie C W, Heng, Pheng-Ann, Castelein, RM, Cheng, Jack C Y Apr 2017 in Scientific Reports 7
• Asymmetry of the Vertebral Body and Pedicles in the True Transverse Plane in Adolescent Idiopathic Scoliosis: A CT-Based Study
  Brink, Rob C., Schlösser, Tom P C, Colo, Dino, Vincken, Koen L., van Stralen, Marijn, Hui, Steve C N, Chu, Winnie C W, Cheng, Jack C Y, Castelein, RM Jan 2017 in Spine Deformity 5 (1), p. 37-45
• Upright, prone, and supine spinal morphology and alignment in adolescent idiopathic scoliosis
  Brink, Rob C, Colo, Dino, Schlösser, Tom P C, Vincken, Koen L, van Stralen, Marijn, Hui, Steve C N, Shi, Lin, Chu, Winnie C W, Cheng, Jack C Y, Castelein, RM 2017 in Scoliosis and spinal disorders 12 p. 6
• The time to progression ratio: A new individualized volumetric parameter for the early detection of clinical benefit of targeted therapies
  Cirkel, G. A., Weeber, F., Bins, S., Gadellaa-van Hooijdonk, C. G M, van Werkhoven, E., Willems, S. M., van Stralen, M., Veldhuis, W. B., Ubink, I., Steeghs, N., de Jonge, M. J., Langenberg, M. H G , Schellens, J. H M, Sleijfer, S., Lolkema, M. P., Voest, Emile E. Aug 2016 in Annals of Oncology 27 (8), p. 1638-1643
• Anterior Overgrowth in Primary Curves, Compensatory Curves and Junctional Segments in Adolescent Idiopathic Scoliosis
  Schlösser, Tom P C, van Stralen, M, Chu, Winnie C W, Lam, Tsz-Ping, Ng, Bobby K W, Vincken, Koen L, Cheng, Jack C Y, Castelein, RM 2016 in PLoS ONE [E] 11 (7), p. e0160267
• IMPROVED SEGMENTATION OF MULTIPLE CAVITIES OF THE HEART IN WIDE-VIEW 3-D TRANSESOPHAGEAL ECHOCARDIOGRAMS
  Haak, Alexander, Ren, Ben, Mulder, Harriet W., Vegas-Sanchez-Ferrero, Gonzalo, van Burken, Gerard, van der Steen, Antonius F. W., van Stralen, M, Pluim, JPW, van Walsum, Theo, Bosch, Johannes G. Jul 2015 in Ultrasound in Medicine and Biology 41 (7), p. 1991-2000
• Segmentation of Multiple Heart Cavities in 3-D Transesophageal Ultrasound Images
  Haak, Alexander, Vegas-Sanchez-Ferrero, Gonzalo, Mulder, Harriet W., Ren, Ben, Kirisli, Hortense A., Metz, Coert, van Burken, Gerard, van Stralen, M, Pluim, JPW, van der Steen, Antonius F. W., van Walsum, Theo, Bosch, Johannes G. Jun 2015 in Ieee transactions on ultrasonics ferroelectrics and frequency control 62 (6), p. 1179-1189
• Arterial and portal venous liver perfusion using selective spin labelling MRI
  Schalkx, Hanke J., Petersen, Esben T., Peters, Nicky H. G. M., Veldhuis, WB, van Leeuwen, MS, Pluim, JPW, van den Bosch, Maurice A. A. J., van Stralen, M Jun 2015 in European Radiology 25 (6), p. 1529-1540
• Detailed imaging and genetic analysis reveal a secondary BRAF(L505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib
  Hoogstraat, Marlous, Gadellaa-van Hooijdonk, Christa G., Ubink, Inge, Besselink, Nicolle J. M., Pieterse, Mark, Veldhuis, Wouter, van Stralen, Marijn, Meijer, Eelco F. J., Willems, Stefan M., Hadders, Michael A., Kuilman, Thomas, Krijgsman, Oscar, Peeper, Daniel S., Koudijs, Marco J., Cuppen, Edwin, Voest, Emile E., Lolkema, Martijn P. May 2015 in Pigment Cell and Melanoma Research 28 (3), p. 318-323
• Seeing More by Showing Less: Orientation-Dependent Transparency Rendering for Fiber Tractography Visualization
  Tax, Chantal M. W., Chamberland, Maxime, van Stralen, Marijn, Viergever, Max A., Whittingstall, Kevin, Fortin, David, Descoteaux, Maxime, Leemans, Alexander Oct 2015 in PLoS ONE [E] 10 (10),
• Full-cycle Left Ventricular Segmentation and Tracking in 3D Echocardiography Using Active Appearance Models
  van Stralen, M, Haak, Alexander, Leung, K. Y. Esther, van Burken, Gerard, Bos, Clemens, Bosch, Johan G. 2015 in Full-cycle Left Ventricular Segmentation and Tracking in 3D Echocardiography Using Active Appearance Models: 2015 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS) p. (IEEE International Ultrasonics Symposium; vol. )
• Atlas-based mosaicing of 3D transesophageal echocardiography images of the left atrium
  Mulder, Harriet W., Pluim, Josien P. W., Ren, Ben, Haak, Alexander, Viergever, Max A., Bosch, Johan G., van Stralen, M 2015 in Atlas-based mosaicing of 3D transesophageal echocardiography images of the left atrium: 2015 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS) p. 1-4 (IEEE International Ultrasonics Symposium; vol. )
• Multiframe registration of real-time three-dimensional echocardiography time series
  Mulder, Harriët, van Stralen, M., van der Zwaan, H.B., Leung, K.Y.E., Bosch, J.G., Pluim, J.P.W. 2014 in Journal of Medical Imaging 1 (1), p. 014004-014004
• Three-dimensional characterization of torsion and asymmetry of the intervertebral discs versus vertebral bodies in adolescent idiopathic scoliosis.
  Schlösser, T.P.C., van Stralen, M., Brink, R.C., Chu, W.C.W., Lam, T-P., Vincken, K.L., Castelein, R.M., Cheng, J.C.Y. 2014 in Spine 39 (19), p. E1159-E1166
• Liver perfusion in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI): comparison of enhancement in Gd-BT-DO3A and Gd-EOB-DTPA in normal liver parenchyma
  Schalkx, H.J., van Stralen, M., Coenegrachts, K., van den Bosch, M.A.A.J., van Kessel, C.S., van Hillegersberg, R., van Erpecum, K.J., Verkooijen, H.M., Pluim, J.P.W., Veldhuis, W.B., van Leeuwen, M.S. 2014 in European Radiology 24 (9), p. 2146-2156
• Evolution of the ablation region after magnetic resonance-guided high-intensity focused ultrasound ablation in a vx2 tumor model
  Wijlemans, J.W., Deckers, R.H.R., van den Bosch, M.A.A.J., Seinstra, B.A., van Stralen, M., van Diest, P.J., Moonen, C.T.W., Bartels, L.W. 2013 in Investigative Radiology 48 (6), p. 381-386
• A transoesophageal echocardiographic image acquisition protocol for wide-view fusion of three-dimensional datasets to support atrial fibrillation catheter ablation
  Ren, B., Mulder, H.W., Haak, A., van Stralen, M., Szili-Torok, T., Pluim, J.P.W., Geleijnse, M.L., Bosch, J.G. 2013 in Journal of Interventional Cardiac Electrophysiology 37 (1), p. 21-26
• Validation of exposure visualization and audible distance emission for navigated temporal bone drilling in phantoms
  Voormolen, E.H.J., Woerdeman, P.A., van Stralen, M., Noordmans, H.J., Viergever, M.A., Regli, L.P.E., Berkelbach van der Sprenkel, J.W. 2012 in PLoS ONE [E] 7 (7), p. e41262
• Determination of a facial nerve safety zone for navigated temporal bone surgery
  Voormolen, E.H.J., van Stralen, M., Woerdeman, P.A., Pluim, J.P.W., Noordmans, H.J., Viergever, M.A., Regli, L.P.E., Berkelbach van der Sprenkel, J.W. 2012 in Neurosurgery 70 (1 suppl operative), p. 50-60 discussion 60
• Targeted vessel ablation for more efficient magnetic resonance-guided high-intensity focused ultrasound ablation of uterine fibroids
  Voogt, M.J., van Stralen, M., Ikink, M.E., Deckers, R.H.R., Vincken, K.L., Bartels, L.W., Mali, W.P.T.M., van den Bosch, M.A.A.J. 2012 in Cardiovascular and Interventional Radiology 35 (5), p. 1205-1210
• Optimal discrete multi-resolution deformable image registration
  van Stralen, M., Pluim, J.P.W. 2009 in Optimal discrete multi-resolution deformable image registration: Proceedings International Symposium on Biomedical Imaging 2009 p. 947-950 (; vol. )
• Left ventricle segmentation from contrast enhanced fast rotating ultrasound images using three dimensional active shape models
  Ma, M., van Stralen, M., Reiber, J.H.C., Bosch, J.G., Lelieveldt, B.P.F. 2009 in Left ventricle segmentation from contrast enhanced fast rotating ultrasound images using three dimensional active shape models: Functional Imaging and Modeling of the Heart p. 295-302 (; vol. )