Hugo Kuijf

Hugo Kuijf (1986) was born in Woerden and grew up in Linschoten, the Netherlands. He completed his Computer Science Bachelor at the Utrecht University in 2007, with academic minors in Software Technology and Game- and Mediatechnology. During his Master Game and Media Technology, he developed an interest in medical image processing. He took extracurricular courses offered by the Biomedical Image Sciences Master programme and finished his Masters' with an internship at the Netherlands Cancer Institute (NKI-AvL), Amsterdam. End of 2009, Hugo started as a PhD-candidate at the Image Sciences Institute (ISI), UMC Utrecht, and focussed on image processing techniques for brain MR images. After completing his PhD in 2013, Hugo continued as a postdoctoral researcher at the ISI.

His research focuses on innovative image processing techniques for the quantification and assessment of brain MR images. These techniques are applied in the context of brain anatomy and pathology, in particular small vessel disease. Advances in MR imaging and the introduction of 7T MR scanners have increased the amount of data and level of detail that can be acquired. Image analysis solutions have become indispensable to quantify and assess brain MR images.

The next goal is to quantify small vessel disease biomarkers, combining the strengths of both clinical 3T and state-of-the-art 7T MR imaging. Semi-automated techniques for the detection of microbleeds, microinfarcts, small arteries and veins, perivascular spaces, and white matter hyperintensities are developed. Translating knowledge and techniques developed at 7T imaging to clinically available 3T imaging is of high interest and will enable broad utilization.

Currently, Hugo is working on the project "Quantitative analysis of MR brain images for cerebrovascular disease management (brainbox)". He co-organized the MICCAI grand challenge on MR brain image segmentation (MRBrainS) workshop in Nagoya (Japan). He developed freely available software for the detection of the midsagittal plane and suface and lesion-symptom mapping.

Publications

• Ex vivo vessel wall thickness measurements of the human circle of Willis using 7T MRI
  Harteveld, Anita A, Denswil, Nerissa P, Van Hecke, Wim, Kuijf, Hugo J, Vink, Aryan, Spliet, Wim G M, Daemen, Mat J, Luijten, Peter R, Zwanenburg, Jaco J M, Hendrikse, Jeroen, van der Kolk, Anja G Apr 2018 in Atherosclerosis 273 p. 106-114
• White matter hyperintensity shape and location feature analysis on brain MRI; Proof of principle study in patients with diabetes
  De Bresser, Jeroen, Kuijf, Hugo J., Zaanen, Karlijn, Viergever, Max A., Hendrikse, Jeroen, Biessels, Geert Jan, Utrecht Vascular Cognitive Impairment Study Group Dec 2018 in Scientific Reports 8 (1),
• Data on vessel wall thickness measurements of intracranial arteries derived from human circle of Willis specimens
  Harteveld, Anita A., Denswil, Nerissa P., Hecke, Wim Van, Kuijf, Hugo J., Vink, Aryan, Spliet, Wim G.M., Daemen, Mat J., Luijten, Peter R., Zwanenburg, Jaco J.M., Hendrikse, Jeroen, Kolk, Anja G. van der 2018 in Data in brief p. -
• Automated Multi-Atlas Segmentation of Hippocampal and Extrahippocampal Subregions in Alzheimer's Disease at 3T and 7T: What Atlas Composition Works Best?
  Xie, Long, Shinohara, Russell T, Ittyerah, Ranjit, Kuijf, Hugo J, Pluta, John B, Blom, Kim, Kooistra, Minke, Reijmer, Yael D, Koek, Huiberdina L, Zwanenburg, Jaco J M, Wang, Hongzhi, Luijten, Peter R, Geerlings, Mirjam I, Das, Sandhitsu R, Biessels, Geert Jan, Wolk, David A, Yushkevich, Paul A, Wisse, Laura E M 2018 in Journal of Alzheimer's Disease 63 (1), p. 217-225
• Evaluation of a deep learning approach for the segmentation of brain tissues and white matter hyperintensities of presumed vascular origin in MRI
  Moeskops, Pim, de Bresser, Jeroen, Kuijf, Hugo J., Mendrik, AM, Biessels, Geert Jan, Pluim, Josien P.W., Išgum, Ivana 2018 in Neuroimage: Clinical [E] 17 p. 251-262
• Evaluation of motion correction for clinical dynamic contrast enhanced MRI of the liver
  Jansen, M. J.A., Kuijf, H. J., Veldhuis, W. B., Wessels, F. J., Van Leeuwen, M. S., Pluim, J. P.W. Sep 2017 in Physics in Medicine and Biology 62 (19), p. 7556-7568
• High-resolution intracranial vessel wall MRI in an elderly asymptomatic population: comparison of 3T and 7T
  Harteveld, Anita A, van der Kolk, Anja G, van der Worp, HB, Dieleman, Nikki, Siero, JCW, Kuijf, Hugo J, Frijns, CJM, Luijten, Peter R, Zwanenburg, Jaco J M, Hendrikse, J Apr 2017 in European Radiology 27 (4), p. 1585–1595
• Reduced vascular amyloid burden at microhemorrhage sites in cerebral amyloid angiopathy
  van Veluw, Susanne J., Kuijf, Hugo J., Charidimou, Andreas, Viswanathan, Anand, Biessels, Geert Jan, Rozemuller, Annemieke J M, Frosch, Matthew P., Greenberg, Steven M. Mar 2017 in Acta Neuropathologica 133 (3), p. 409-415
• Evolution of cerebral microbleeds after cranial irradiation in medulloblastoma patients
  Roongpiboonsopit, Duangnapa, Kuijf, Hugo J., Charidimou, Andreas, Xiong, Li, Vashkevich, Anastasia, Martinez-Ramirez, Sergi, Shih, Helen A., Gill, Corey M., Viswanathan, Anand, Dietrich, Jorg Feb 2017 in Neurology 88 (8), p. 789-796
• Corrigendum to “The right hemisphere is dominant in organization of visual search—A study in stroke patients” [Behav. Brain Res. 304 (2016) 71–79]((S0166432816300626)(10.1016/j.bbr.2016.02.004))
  ten Brink, Antonia F., Biesbroek, J. Matthijs, Kuijf, Hugo J., Van der Stigchel, Stefan, Oort, Quirien, Visser-Meily, Johanna M A, Nijboer, Tanja C W Feb 2017 in Behavioural Brain Research 319 p. 234
• Morphological characteristics of diffuse idiopathic skeletal hyperostosis in the cervical spine
  Bakker, Jessica T, Kuperus, Jonneke S , Kuijf, Hugo J, Oner, F Cumhur, de Jong, Pim A, Verlaan, Jorrit-Jan Nov 2017 in PLoS ONE [E] 12 (11),
• Strategic infarct location for post-stroke cognitive impairment: A multivariate lesion-symptom mapping study
  Zhao, Lei, Biesbroek, J. Matthijs, Shi, Lin, Liu, Wenyan, Kuijf, Hugo J., Chu, Winnie W.C., Abrigo, Jill M., Lee, Ryan K.L., Leung, Thomas W.H., Lau, Alexander Y.L., Biessels, Geert J., Mok, Vincent, Wong, Adrian Jan 2017 in Journal of Cerebral Blood Flow and Metabolism p. 271678X17728162
• Body representation disorders predict left right orientation impairments after stroke: A voxel-based lesion symptom mapping study
  van Stralen, Haike E., Dijkerman, H. Chris, Biesbroek, J. Matthijs, Kuijf, Hugo J., van Gemert, H. Maarten A, Sluiter, David, Kappelle, L. Jaap, van Zandvoort, Martine J.E. 2017 in Cortex
• Abnormalities of Cerebral Deep Medullary Veins on 7 Tesla MRI in Amnestic Mild Cognitive Impairment and Early Alzheimer's Disease: A Pilot Study
  Bouvy, Willem H, Kuijf, Hugo J, Zwanenburg, Jaco J M, Koek, Huiberdina L, Kappelle, L Jaap, Luijten, Peter R, Ikram, M Kamran, Biessels, Geert Jan, Utrecht Vascular Cognitive Impairment (VCI) Study group 2017 in Journal of Alzheimer's Disease 57 (3), p. 705-710
• Visuospatial Functioning in Cerebral Amyloid Angiopathy: A Pilot Study
  Valenti, Raffaella, Charidimou, Andreas, Xiong, Li, Boulouis, Gregoire, Fotiadis, Panagiotis, Ayres, Alison, Riley, Grace, Kuijf, Hugo J., Reijmer, Yael D., Pantoni, Leonardo, Gurol, M. Edip, Davidsdottir, Sigurros, Greenberg, Steven M., Viswanathan, Anand 2017 in Journal of Alzheimer's Disease 56 (4), p. 1223-1227
• Cover Image, Volume 29, Issue 9
  Bouvy, W. H., Geurts, L. J., Kuijf, H. J., Luijten, P. R., Kappelle, L. J., Biessels, G. J., Zwanenburg, J. J M Sep 2016 in NMR in Biomedicine 29 (9), p. 1
• Assessment of blood flow velocity and pulsatility in cerebral perforating arteries with 7-T quantitative flow MRI
  Bouvy, W. H., Geurts, L. J., Kuijf, H. J., Luijten, P. R., Kappelle, L. J., Biessels, G. J., Zwanenburg, J. J M Sep 2016 in NMR in Biomedicine 29 (9), p. 1295-1304
• Strong evidence for pattern separation in human dentate gyrus
  Berron, David, Schütze, Hartmut, Maass, Anne, Cardenas-Blanco, Arturo, Kuijf, Hugo J., Kumaran, Dharshan, Düzel, Emrah Jul 2016 in Journal of Neuroscience 36 (29), p. 7569-7579
• Automated hippocampal subfield segmentation at 7T MRI
  Wisse, L. E M, Kuijf, H. J., Honingh, A. M., Wang, H., Pluta, J. B., Das, S. R., Wolk, D. A., Zwanenburg, J. J M, Yushkevich, P. A., Geerlings, M. I. Jun 2016 in American Journal of Neuroradiology 37 (6), p. 1050-1057
• The right hemisphere is dominant in organization of visual search-A study in stroke patients
  Ten Brink, Antonia F., Biesbroek, Matthijs, Kuijf, Hugo J., Van der Stigchel, Stefan, Oort, Quirien, Visser-Meily, Johanna M A, Nijboer, Tanja C W May 2016 in Behavioural Brain Research 304 p. 71-79
• Impact of Strategically Located White Matter Hyperintensities on Cognition in Memory Clinic Patients with Small Vessel Disease
  Biesbroek, J. Matthijs, Weaver, Nick A., Hilal, Saima, Kuijf, Hugo J., Ikram, Kamran, Xu, Xin, Tan, Boon Yeow, Venketasubramanian, Narayanaswamy, Postma, Albert, Biessels, Geert Jan, Chen, Christopher P L H Nov 2016 in PLoS ONE [E] 11 (11),
• Quantification of deep medullary veins at 7 T brain MRI
  Kuijf, Hugo J., Bouvy, Willem H., Zwanenburg, Jaco J M, Schultz, Tom B Razoux, Viergever, Max A., Vincken, Koen L., Biessels, Geert Jan Oct 2016 in European Radiology 26 (10), p. 3412-3418
• Erratum to "Subfields of the hippocampal formation at 7T MRI: In vivo volumetric assessment" [NeuroImage 61 (2012) 1043-1049]
  Wisse, L. E M, Gerritsen, L., Zwanenburg, J. J M, Kuijf, H. J., Luijten, P. R., Biessels, G. J., Geerlings, M. I. Jan 2016 in Neuroimage 125 p. 1176-1177
• Employing visual analytics to aid the design of white matter hyperintensity classifiers
  Raidou, Renata Georgia, Kuijf, Hugo J., Sepasian, Neda, Pezzotti, Nicola, Bouvy, Willem H., Breeuwer, Marcel, Vilanova, Anna 2016 in Medical Image Computing and Computer-Assisted Intervention - MICCAI 2016: 19th International Conference, Proceedings Springer Verlag p. 97-105 (Lecture Notes in Computer Science; vol. 9901)
• Supervised novelty detection in brain tissue classification with an application to white matter hyperintensities
  Kuijf, Hugo J., Moeskops, Pim, De Vos, Bob D., Bouvy, Willem H., De Bresser, Jeroen, Biessels, Geert Jan, Viergever, Max A., Vincken, Koen L. 2016 in Medical Imaging 2016:Image Processing: 1–3 March 2016 San Diego, California, United States SPIE p. (Proceedings of SPIE; vol. 9784)
• Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients
  Van Veluw, Susanne J., Hilal, Saima, Kuijf, Hugo J., Ikram, Mohammad Kamran, Xin, Xu, Yeow, Tan Boon, Venketasubramanian, Narayanaswamy, Biessels, Geert Jan, Chen, Christopher Dec 2015 in Alzheimer's & Dementia 11 (12), p. 1500-1509
• Microstructural brain abnormalities in Huntington's disease: A two-year follow-up
  Odish, Omar F F, Leemans, A, Reijntjes, Robert H A M, van den Bogaard, Simon J A, Dumas, Eve M., Wolterbeek, Ron, Tax, Chantal M W, Kuijf, Hugo J., Vincken, Koen L., van der Grond, Jeroen, Roos, Raymund A C Jan 2015 in Human Brain Mapping 36 (6), p. 2061-2074
• Distinct anatomical correlates of discriminability and criterion setting in verbal recognition memory revealed by lesion-symptom mapping
  Biesbroek, J. Matthijs, van Zandvoort, Martine J E, Kappelle, L. Jaap, Schoo, Linda, Kuijf, Hugo J., Velthuis, BK, Biessels, Geert Jan, Postma, Albert Jan 2015 in Human Brain Mapping 36 (4), p. 1292-1303
• Hippocampal Disconnection in Early Alzheimer's Disease: A 7 Tesla MRI Study
  Wisse, Laura E. M., Reijmer, Yael D., ter Telgte, Annemieke, Kuijf, Hugo J., Leemans, Alexander, Luijten, Peter R., Koek, Huiberdina L., Geerlings, Mirjam I., Biessels, Geert Jan, Utrecht Vasc Cognitive Impairment 2015 in Journal of Alzheimer's Disease 45 (4), p. 1247-1256
• MRBrainS Challenge: Online Evaluation Framework for Brain Image Segmentation in 3T MRI Scans
  Mendrik, Adriënne M., Vincken, Koen L., Kuijf, Hugo J., Breeuwer, Marcel, Bouvy, Willem H., De Bresser, Jeroen, Alansary, Amir, De Bruijne, Marleen, Carass, Aaron, El-Baz, Ayman, Jog, Amod, Katyal, Ranveer, Khan, Ali R., Van Der Lijn, Fedde, Mahmood, Qaiser, Mukherjee, Ryan, Van Opbroek, Annegreet, Paneri, Sahil, Pereira, Sérgio, Persson, Mikael, Rajchl, Martin, Sarikaya, Duygu, Smedby, Örjan, Silva, Carlos A., Vrooman, Henri A., Vyas, Saurabh, Wang, Chunliang, Zhao, Liang, Biessels, Geert Jan, Viergever, Max A. 2015 in Computational Intelligence and Neuroscience 2015
• Cerebral microbleeds after whole brain radiation therapy in medulloblastoma patients
  Roongpiboonsopit, Duangnapa, Alstein, Lily, Kuijf, HJ, Charidimou, Andreas, Xiong, Li, Vashkevich, Anastasia, Martinez-Ramirez, Sergi, Shih, Helen, Viswanathan, Anand, Dietrich, Jorg 2015 at 20th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology
• Automated detection of periventricular veins on 7 T brain MRI
  Kuijf, Hugo J., Bouvy, Willem H., Zwanenburg, Jaco J M, Viergever, Max A., Biessels, Geert Jan, Vincken, Koen L. 2015 in Progress in Biomedical Optics and Imaging - Proceedings of SPIE: SPIE p. (; vol. )
• The added value of diffusion tensor imaging for automated white matter hyperintensity segmentation
  Kuijf, Hugo J., Tax, Chantal M W, Zaanen, L. Karlijn, Bouvy, Willem H., de Bresser, Jeroen, Leemans, Alexander, Viergever, Max A., Biessels, Geert Jan, Vincken, Koen L. 2014 in Mathematics and Visualization: Springer Berlin Heidelberg p. 45-53 (Mathematics and Visualization; vol. 39)
• Tracking of cell nuclei for assessment of in vitro uptake kinetics in ultrasound-mediated drug delivery using fibered confocal fluorescence microscopy
  Derieppe, M.P.P., de Senneville, B.D., Kuijf, H.J., Moonen, C.T.W., Bos, C. 2014 in Molecular Imaging and Biology 16 (5), p. 642-651
• Visualization of perivascular spaces and perforating arteries with 7 T magnetic resonance imaging
  Bouvy, W.H., Biessels, G.J., Kuijf, H.J., Kappelle, L.J., Luijten, P.R., Zwanenburg, J.J.M. 2014 in Investigative Radiology 49 (5), p. 307-313
• Automatic extraction of the midsagittal surface from brain MR images using the kullback-leibler measure
  Kuijf, H.J., van Veluw, S.J., Geerlings, M.I., Viergever, M.A., Biessels, G.J., Vincken, K.L. 2014 in Neuroinformatics 12 (3), p. 395-403
• Visualization of the aneurysm wall: a 7.0-tesla magnetic resonance imaging study
  Kleinloog, R., Korkmaz, E., Zwanenburg, J.J.M., Kuijf, H.J., Visser, F., Blankena, R., Post, J.A., Ruigrok, Y.M., Luijten, P.R., Regli, L.P.E., Rinkel, G.J.E., Verweij, B.H. 2014 in Neurosurgery 75 (6), p. 614-622
• Hippocampal subfield volumes at 7T in early Alzheimer's disease and normal aging
  Wisse, L.E.M., Biessels, G.J., Heringa, S.M., Kuijf, H.J., Koek, D.H., Luijten, P.R., Utrecht Vascular Cognitive Impairment Study Group, x, et al, X, Geerlings, M.I. 2014 in Neurobiology of Aging 35 (9), p. 2039-2045
• Cerebral microvascular lesions on high-resolution 7-tesla MRI in patients with type 2 diabetes
  Brundel, M., Reijmer, Y.D., van Veluw, S.J., Kuijf, H.J., Luijten, P.R., Kappelle, L.J., Algra, A., Rutten, G.E.H.M., Utrecht Vascular Cognitive Impairment Study Group, x, Biessels, G.J. 2014 in Diabetes 63 (10), p. 3523-3529
• Cerebral cortical microinfarcts at 7Tesla MRI in patients with early Alzheimer's disease
  van Veluw, S.J., Heringa, S.M., Kuijf, H.J., Koek, H.L., Luijten, P.R., Utrecht Vascular Cognitive Impairment Study Group, x, et al, X, Biessels, G.J. 2014 in Journal of Alzheimer's Disease 39 (1), p. 163-167
• The anatomy of visuospatial construction revealed by lesion-symptom mapping
  Biesbroek, J.M., van Zandvoort, M.J.E., Kuijf, H.J., Weaver, N.A., Kappelle, L.J., Vos, P.C., Velthuis, B.K., Biessels, G.J., Utrecht Vascular Cognitive Impairment Study Group, x, et al, X, Postma, A. 2014 in Neuropsychologia 62 (1), p. 68-76
• Assessment of methods to extract the mid-sagittal plane from brain MR images
  Kuijf, H.J., Leemans, A., Viergever, M.A., Vincken, K.L. mar 2013 in SPIE Medical Imaging: p. 86731K (; vol. )
• Detecting cortical cerebral microinfarcts in 7.0 T MR images
  Kuijf, HJ, Zijlstra, F, van Veluw, SJ, Viergever, MA, Vincken, KL, Biessels, GJ 2013 at 2013 IEEE 10th International Symposium on Biomedical Imaging
• Registration of Brain CT Images to an MRI Template for the Purpose of Lesion-Symptom Mapping
  Kuijf, HJ, Biesbroek, JM, Viergever, MA, Biessels, GJ, Vincken, KL 2013 in Multimodal Brain Image Analysis: p. (Lecture Notes in Computer Science; vol. 8159)
• How to assess the reliability of cerebral microbleed rating?
  Kuijf, H.J., van Veluw, S.J., Viergever, M.A., Vincken, K.L., Biessels, G.J. 2013 in Frontiers in Aging Neuroscience [E] 5 p. 57
• Quantitative analysis of the closure pattern of the neurocentral junction as related to preexistent rotation in the normal immature spine.
  Schlosser, T.P., Vincken, K.L., Attrach, H., Kuijf, H.J., Viergever, M.A., Janssen, M.M.A., Castelein, R.M. 2013 in The Spine Journal 13 (7), p. 756-763
• Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study
  Biesbroek, J.M., Kuijf, H.J., van der Graaf, Y., Vincken, K.L., Postma, A., Mali, W.P.T.M., Biessels, G.J., Algra, A., Doevendans, P.A., Grobbee, D.E., Rutten, G.E.H.M., Kappelle, L.J., Moll, F.L., Visseren, F.L.J., SMART Study Group, x, Geerlings, M.I. 2013 in PLoS ONE [E] 8 (4), p. e60541
• Hippocampal T2 hyperintensities on 7 Tesla MRI
  van Veluw, S.J., Wisse, L.E.M., Kuijf, H.J., Spliet, W.G.M., Hendrikse, J., Luijten, P.R., Geerlings, M.I., Biessels, G.J. 2013 in Neuroimage: Clinical [E] 3 p. 196-201
• Semi-automated detection of cerebral microbleeds on 3.0 T MR images
  Kuijf, H.J., Brundel, M., de Bresser, J.H.J.M., van Veluw, S.J., Heringa, S.M., Viergever, M.A., Biessels, G.J., Vincken, K.L. 2013 in PLoS ONE [E] 8 (6), p. e66610
• Subfields of the hippocampal formation at 7T MRI: In vivo volumetric assessment
  Wisse, L. E.M., Gerritsen, L., Zwanenburg, J. J.M., Kuijf, H. J., Luijten, P. R., Biessels, G. J., Geerlings, M. I. Jul 2012 in Neuroimage 61 (4), p. 1043-1049
• Subfields of the hippocampal formation at 7 T MRI: in vivo volumetric assessment.
  Wisse, L.E.M., Gerritsen, L., Zwanenburg, J.J.M., Kuijf, H.J., Luijten, P.R., Biessels, G.J., Geerlings, M.I. 2012 in Neuroimage 61 (4), p. 1043-1049
• Efficient detection of cerebral microbleeds on 7.0T MR images using the radial symmetry transform
  Kuijf, H.J., de Bresser, J.H.J.M., Geerlings, M.I., Conijn, M.M.A., Viergever, M.A., Biessels, G.J., Vincken, K.L. 2012 in Neuroimage 59 (3), p. 2266-2273
• Detecting cerebral microbleeds in 7.0 T MR images using the radial symmetry transform
  Kuijf, HJ, de Bresser, JHJM, Biessels, GJ, Viergever, MA, Vincken, KL 2011 in 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11: IEEE p. 758-761 (; vol. )