Edwin Bennink

Edwin Bennink works as a researcher and scientific software engineer for the Medical Physics Group and the Image Sciences Institute (UMC Utrecht - Dept. of Radiology).

He received the MSc degree (cum laude) in biomedical engineering from the Eindhoven University of Technology in 2007. In 2016, he received his PhD from the Utrecht University, with a research project on quantitative CT brain perfusion analysis. From 2007 to 2011 he worked as senior software developer for Scientific Volume Imaging BV.

Besides doing research in CT imaging in acute stroke and supporting various image-analysis related projects throughout the UMC Utrecht, Edwin is one of the lead developers of IMAGR, the image analytics infrastructure that brings deep-learning algorithms into the clinical workflow.

Publications

• The relationship of fat and muscle measurements with emphysema and bronchial wall thickening in smokers
  Bunk, Stijn, Ipema, Jetty, Sidorenkov, Grigory, Bennink, E, Vliegenthart, Rozemarijn, de Jong, Pim, Pompe, Esther, Charbonnier, Jean-Paul, Luijk, B., Aerts, Joachim, Groen, Harry, Mohamed Hoesein, Firdaus Mar 2024 in ERJ Open Research 10 (2),
• Standardizing the estimation of ischemic regions can harmonize CT perfusion stroke imaging
  Peerlings, Daan, Bennink, Edwin, Dankbaar, Jan W, Velthuis, Birgitta K, Emmer, Bart J, Hoving, Jan W, Majoie, Charles B L M, Marquering, Henk A, van Voorst, Henk, de Jong, Hugo W A M, CLEOPATRA (cost-effectiveness of CT perfusion for patients with acute ischemic stroke) healthcare evaluation, DUST (Dutch acute stroke) study investigators Feb 2024 in European Radiology 34 (2), p. 797-807
• A monocenter, patient-blinded, randomized, parallel-group, non-inferiority study to compare cochlear implant receiver/stimulator device fixation techniques (COMFIT) with and without drilling in adults eligible for primary cochlear implantation
  Markodimitraki, Laura M., Harkel, Timen C.ten, Bennink, Edwin, Stegeman, Inge, Thomeer, Hans G.X.M. Sep 2023 in Trials [E] 24 (1), p. 1-10
• Detection of Cardioembolic Sources With Nongated Cardiac Computed Tomography Angiography in Acute Stroke: Results From the ENCLOSE Study
  Kauw, Frans, Velthuis, Birgitta K, Takx, Richard A P, Guglielmo, Marco, Cramer, Maarten J, van Ommen, Fasco, Bos, Anneloes, Bennink, Edwin, Marquering, Henk A., Kappelle, L Jaap, de Jong, Hugo W A M, Dankbaar, Jan W Mar 2023 in Stroke 54 (3), p. 821-830
• Neural network-derived perfusion maps: A model-free approach to computed tomography perfusion in patients with acute ischemic stroke
  Gava, Umberto A., D’Agata, Federico, Tartaglione, Enzo, Renzulli, Riccardo , Grangetto, Marco , Bertolino, Francesca , Santonocito, Ambra , Bennink, E, Vaudano, Giacomo , Boghi, Andrea , Bergui, Mauro Mar 2023 in Frontiers in Neuroinformatics [E] 17
• Spatial CT perfusion data helpful in automatically locating vessel occlusions for acute ischemic stroke patients
  Peerlings, D, de Jong, Hugo, Bennink, E, Dankbaar, Jan Willem, Velthuis, Birgitta, Emmer, Bart J, Majoie, C.B., Marquering, H. A., Dutch acute Stroke Study (DUST) investigators Mar 2023 in Frontiers in Neurology 14
• Cerebrospinal fluid volume improves prediction of malignant edema after endovascular treatment of stroke
  Kauw, Frans, Bernsen, Marie Louise, Dankbaar, Jan Willem, de Jong, Hugo, Kappelle, Jaap, Velthuis, Birgitta K, Van der Worp, H B, van der Lugt, Aad, Roos, Y B, Yo, Lonneke, van Walderveen, Marianne Aa, Hofmeijer, Jeannette, Bennink, Edwin Feb 2023 in International Journal of Stroke 18 (2), p. 187-192
• Probability maps classify ischemic stroke regions more accurately than CT perfusion summary maps
  Peerlings, Daan, van Ommen, Fasco, Bennink, Edwin, Dankbaar, Jan Willem, Velthuis, Birgitta, Emmer, Bart J, Hoving, Jan W., Majoie, Charles B.L.M., Marquering, Henk A., de Jong, Hugo W.A.M. Sep 2022 in European Radiology 32 (9), p. 6367-6375
• Motion correction in retinal optical coherence tomography imaging using deep learning registration
  Ntatsis, Konstantinos , Sánchez Brea, Luisa, Andrade De Jesus, Danilo, Barbosa-Breda, João, van Walsum, Theo, Bennink, E, Klein, Stefan apr 2022 in Motion correction in retinal optical coherence tomography imaging using deep learning registration: Medical Imaging 2022: Image Processing p. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 12032)
• Comparing methods of detecting and segmenting unruptured intracranial aneurysms on TOF-MRAS: The ADAM challenge
  Timmins, Kimberley, van der Schaaf, Irene, Bennink, E, Ruigrok, Ynte, Velthuis, BK, Kuijf, Hugo Sep 2021 in NeuroImage 238
• Bringing AI to the clinic: blueprint for a vendor-neutral AI deployment infrastructure
  Leiner, Tim, Bennink, E, Mol, Christian, Kuijf, Hugo, Veldhuis, WB Dec 2021 in Insights Into Imaging [E] 12 (1), p. 11
• Non-contrast dual-energy CT virtual ischemia maps accurately estimate ischemic core size in large-vessel occlusive stroke
  Wolman, Dylan N., van Ommen, Fasco, Tong, Elizabeth, Kauw, Frans, Dankbaar, Jan Willem, Bennink, E, de Jong, Hugo, Molvin, Lior, Wintermark, Max, Heit, Jeremy J Dec 2021 in Scientific Reports 11 (1),
• Variation in arterial input function in a large multicenter computed tomography perfusion study
  On behalf of the DUtch acute STroke (DUST) study investigators Nov 2021 in European Radiology 31 (11), p. 8317-8325
• Image Quality of Virtual Monochromatic Reconstructions of Noncontrast CT on a Dual-Source CT Scanner in Adult Patients
  van Ommen, Fasco, Kauw, Frans, Bennink, E, Heit, Jeremy J, Wolman, Dylan N., Dankbaar, Jan Willem, de Jong, H.W.A.M., Wintermark, Max Oct 2021 in Academic Radiology 28 (10), p. e323-e330
• Improving the Quality of Cerebral Perfusion Maps With Monoenergetic Dual-Energy Computed Tomography Reconstructions
  van Ommen, Fasco, Bennink, E, Dankbaar, Jan Willem, Kauw, Frans, de Jong, H.W.A.M. Jan 2021 in Journal of Computer Assisted Tomography 45 (1), p. 103-109
• Virtual monochromatic dual-energy CT reconstructions improve detection of cerebral infarct in patients with suspicion of stroke
  van Ommen, Fasco, Dankbaar, Jan Willem, Zhu, Guangming, Wolman, Dylan N., Heit, Jeremy J, Kauw, Frans, Bennink, E, de Jong, Hugo, Wintermark, Max Jan 2021 in Neuroradiology 63 (1), p. 41-49
• A Reflectivity Measure to Quantify Bruch's Membrane Calcification in Patients with Pseudoxanthoma Elasticum Using Optical Coherence Tomography
  Risseeuw, Sara, Bennink, E, Poirot, Maarten, de Jong, Pim, Spiering, Wilko, Imhof, Saskia, van Leeuwen, R, Ossewaarde-van Norel, J Jul 2020 in Translational Vision Science and Technology 9 (8), p. 34
• Prediction of Malignant Edema Formation After Endovascular Treatment for Middle Cerebral Artery Infarction: The Added Value of Intracranial Cerebrospinal Fluid Volume
  Kauw, Frans, Bernsen, Marie Louise E., de Jong, H.W.A.M., Kappelle, Jaap, Velthuis, BK, van der worp, B, van der Lugt, Aad, Roos, Y.B., Hofmeijer, Jeannette, Dankbaar, Jan Willem, Bennink, E, MR CLEAN Registry Investigators feb 2020 in Prediction of Malignant Edema Formation After Endovascular Treatment for Middle Cerebral Artery Infarction:The Added Value of Intracranial Cerebrospinal Fluid Volume INTERNATIONAL STROKE CONFERENCE 2020 p. (; vol. )
• Early detection of small volume stroke and thromboembolic sources with computed tomography: Rationale and design of the ENCLOSE study
  Kauw, Frans, van Ommen, Fasco, Bennink, Edwin, Cramer, Maarten J, Kappelle, L Jaap, Takx, Richard Ap, Velthuis, Birgitta K, Viergever, Max A, Wouter van Es, H, Schonewille, Wouter J, Coutinho, Jonathan M, Majoie, Charles Blm, Marquering, Henk A, de Jong, Hugo Wam, Dankbaar, Jan W Dec 2020 in European Stroke Journal 5 (4), p. 432-440
• From perviousness to permeability, modelling and measuring intra-thrombus flow in acute ischemic stroke
  Arrarte Terreros, Nerea, Tolhuisen, Manon L., Bennink, E, de Jong, Hugo, Beenen, Ludo F. M., Majoie, Charles B.L.M., van Bavel, Ed Oct 2020 in Journal of Biomechanics 111
• Effect of prolonged acquisition intervals for CT-perfusion analysis methods in patients with ischemic stroke
  van Ommen, F, Kauw, F, Bennink, E, Dankbaar, JW, Viergever, MA, de Jong, HWAM Jul 2019 in Medical Physics 46 (7), p. 3156-3164
• Intracranial Cerebrospinal Fluid Volume as a Predictor of Malignant Middle Cerebral Artery Infarction
  Kauw, Frans, Bennink, Edwin, De Jong, Hugo W.A.M., Kappelle, L. Jaap, Horsch, Alexander D., Velthuis, Birgitta K., Dankbaar, Jan W., DUST Investigators Jun 2019 in Stroke 50 (6), p. 1437-1443
• Comparison of Place-versus-Pitch Mismatch between a Perimodiolar and Lateral Wall Cochlear Implant Electrode Array in Patients with Single-Sided Deafness and a Cochlear Implant
  Peters, JPM, Bennink, E, van Zanten, GA Apr 2019 in Audiology & Neuro-otology 24 (1), p. 38-48
• Dose of CT protocols acquired in clinical routine using a dual-layer detector CT scanner: A preliminary report
  van Ommen, F, de Jong, HWAM, Dankbaar, JW, Bennink, E, Leiner, T, Schilham, AMR Mar 2019 in European Journal of Radiology 112 p. 65-71
• Stroke progression and clinical outcome in ischemic stroke patients with a history of migraine
  Mulder, Inge A, Holswilder, Ghislaine, van Walderveen, Marianne Aa, van der Schaaf, Irene C, Bennink, Edwin, Horsch, Alexander D, Kappelle, L Jaap, Velthuis, Birgitta K, Dankbaar, Jan Willem, Terwindt, Gisela M, Schonewille, Wouter J, Visser, Marieke C, Ferrari, Michel D, Algra, Ale, Wermer, Marieke Jh, DUST Investigators Dec 2019 in International Journal of Stroke 14 (9), p. 946-955
• Quantification of Bruch’s Membrane calcification in Pseudoxanthoma Elasticum: a proof‐of‐concept study using SD‐OCT
  Risseeuw, Sara, Bennink, E, Poirot, Maarten, Imhof, Saskia, van Leeuwen, R, Ossewaarde-van Norel, J dec 2019 in Quantification of Bruch’s Membrane calcification in Pseudoxanthoma Elasticum:a proof‐of‐concept study using SD‐OCT Abstracts from the 2019 European Association for Vision and Eye Research Conference p. (ACTA OPHTHALMOLOGICA; vol. )
• Wake-up stroke versus stroke with known onset time: clinical and multimodality CT imaging characteristics
  Dankbaar, Jan W., Bienfait, Henri P., Van Den Berg, Coen, Bennink, Edwin, Horsch, Alexander D., Van Seeters, Tom, Van Der Schaaf, Irene C., Kappelle, L. Jaap, Velthuis, Birgitta K. Aug 2018 in Cerebrovascular Diseases 45 ( 5-6), p. 236-244
• Image quality of conventional images of dual-layer SPECTRAL CT: a phantom study
  van Ommen, F, Bennink, E, Vlassenbroek, A, Dankbaar, J W, Schilham, A M R, Viergever, M A, de Jong, H W A M Jul 2018 in Medical Physics 45 (7), p. 3031-3042
• Computed Tomography Perfusion Derived Blood-Brain Barrier Permeability Does Not Yet Improve Prediction of Hemorrhagic Transformation
  Horsch, Alexander D., Bennink, Edwin, van Seeters, Tom, Kappelle, L. Jaap, van der Graaf, Yolanda, Mali, Willem P.T.M., de Jong, Hugo W.A.M., Velthuis, Birgitta K., Dankbaar, Jan Willem 2018 in Cerebrovascular Diseases 45 (1-2), p. 26-32
• Automatic Localization of Cochlear Implant Electrode Contacts in CT
  Bennink, Edwin, Peters, Jeroen P M, Wendrich, Anne W., Vonken, Evert jan, van Zanten, Gijsbert A., Viergever, Max A. 2017 in Ear and Hearing 38 (6), p. e376-e384
• Fast nonlinear regression method for CT brain perfusion analysis
  Bennink, Edwin, Oosterbroek, Jaap, Kudo, Kohsuke, Viergever, Max A, Velthuis, BK, de Jong, Hugo W A M Apr 2016 in Journal of Medical Imaging 3 (2),
• Electro-acoustic pitch matching experiments in patients with single-sided deafness and a cochlear implant: Is there a need for adjustment of the default frequency allocation tables?
  Peters, Jeroen P M, Bennink, Edwin, Grolman, Wilko, van Zanten, Gijsbert A Dec 2016 in Hearing Research 342 p. 124-133
• Imaging Findings Associated with Space-Occupying Edema in Patients with Large Middle Cerebral Artery Infarcts
  Horsch, A D, Dankbaar, J W, Stemerdink, T A, Bennink, E, van Seeters, T, Kappelle, L J, Hofmeijer, J, de Jong, H W, van der Graaf, Y, Velthuis, B K, DUST Investigators 2016 in American Journal of Neuroradiology 37 (5), p. 831-837
• Influence of Thin Slice Reconstruction on CT Brain Perfusion Analysis
  Bennink, Edwin, Oosterbroek, Jaap, Horsch, Alexander D., Dankbaar, Jan Willem, Velthuis, BK, Viergever, Max A., de Jong, Hugo W. A. M. Sep 2015 in PLoS ONE [E] 10 (9),
• CT perfusion analysis by nonlinear regression for predicting hemorrhagic transformation in ischemic stroke
  Bennink, Edwin, Horsch, Alexander D., Dankbaar, Jan Willem, Velthuis, BK, Viergever, Max A., de Jong, Hugo W. A. M. Aug 2015 in Medical Physics 42 (8), p. 4610-4618
• Comparison of DCE-CT models for quantitative evaluation of K-trans in larynx tumors
  Oosterbroek, J., Bennink, E., Philippens, M. E P, Raaijmakers, C. P J, Viergever, M. A., De Jong, H. W A M May 2015 in Physics in Medicine and Biology 60 (9), p. 3759-3773
• Different CT perfusion algorithms in the detection of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
  Cremers, Charlotte H P, Dankbaar, Jan Willem, Vergouwen, Mervyn D I, Vos, Pieter C., Bennink, Edwin, Rinkel, Gabriel J E, Velthuis, Birgitta K., van der Schaaf, Irene C. May 2015 in Neuroradiology 57 (5), p. 469-474
• A non-linear regression method for CT brain perfusion analysis
  Bennink, Edwin, Oosterbroek, J., Viergever, M. A., Velthuis, B. K., De Jong, H. W A M 2015 in A non-linear regression method for CT brain perfusion analysis: Progress in Biomedical Optics and Imaging - Proceedings of SPIE p. (; vol. )
• Predicting stroke outcome using DCE-CT measured blood velocity
  Oosterbroek, Jaap, Bennink, Edwin, Dankbaar, Jan Willem, Horsch, Alexander D., Viergever, Max A., Velthuis, BK, De Jong, Hugo W A M 2015 in Predicting stroke outcome using DCE-CT measured blood velocity: Progress in Biomedical Optics and Imaging - Proceedings of SPIE p. (; vol. )
• Automated prediction of tissue outcome after acute ischemic stroke in Computed Tomography perfusion images
  Vos, Pieter C., BEnnink, Edwin, de Jong, H.W.A.M., Velthuis, BK, Viergever, Max A., Dankbaar, Jan Willem 2015 in Automated prediction of tissue outcome after acute ischemic stroke in Computed Tomography perfusion images: MEDICAL IMAGING 2015: COMPUTER-AIDED DIAGNOSIS p. (Proceedings of SPIE; vol. 9414)
• High performance analysis of compressed dynamic CT perfusion image data for acute care of ischemic stroke
  Barros, R.S., Bennink, E, Posthuma, J., Oosterbroek, J, Majoie, C., de Jong, HWAM, Olabarriaga, S.D., Marquering, H. A. 2015 in High performance analysis of compressed dynamic CT perfusion image data for acute care of ischemic stroke: HPC-MICCAI 2015 p. (; vol. )
• Comparison of partial volume effects in arterial and venous contrast curves in CT brain perfusion imaging
  Riordan, A.J., Bennink, H.E., Dankbaar, J.W., Viergever, M.A., Velthuis, B.K., Smit, E.J., de Jong, H.W.A.M. 2014 in PLoS ONE [E] 9 (5), p. e97586
• A fast nonlinear regression method for estimating permeability in CT perfusion imaging
  Bennink, H.E., Riordan, A.J., Horsch, A.D., Dankbaar, J.W., Velthuis, B.K., de Jong, H.W.A.M. 2013 in Journal of Cerebral Blood Flow and Metabolism 33 (11), p. 1743-1751
• CT brain perfusion protocol to eliminate the need for selecting a venous output function
  Riordan, A.J., Bennink, H.E., Viergever, M.A., Velthuis, B.K., Dankbaar, J.W., de Jong, H.W.A.M. 2013 in American Journal of Neuroradiology 34 (7), p. 1353-1358
• A novel 3d multi-scale lineness filter for vessel detection
  Bennink, E, van Assen, H.C., Streekstra, G.J., ter Wee, R., Spaan, J.A.E., ter Haar Romeny, B.M. 2007 in A novel 3d multi-scale lineness filter for vessel detection: Medical Image Computing and Computer-Assisted Intervention–MICCAI 2007 p. 436-443 (Lecture Notes in Computer Science; vol. )
• Warping a neuro-anatomy atlas on 3D MRI data with radial basis functions
  Bennink, E, Korbeeck, J.M., Janssen, B.J., ter Haar Romeny, B.M. 2007 in Warping a neuro-anatomy atlas on 3D MRI data with radial basis functions: 3rd Kuala Lumpur International Conference on Biomedical Engineering 2006 p. 28-32 (; vol. )